منابع مشابه
Small molecules for big tasks.
One of the most important achievements in the post-genome era is discovery of microRNAs (miRNAs), which widely exist from simple-genome organisms such as viruses and bacteria to complex-genome organisms such as plants and animals. miRNAs are single-stranded non-coding RNAs of 18– 25 nucleotides in length, which are generated from larger precursors that are transcribed from non-coding genes. As ...
متن کاملThinking big with small molecules
Synthetic chemistry has enabled scientists to explore the frontiers of cell biology, limited only by the laws of chemical bonding and reactivity. As we investigate biological questions of increasing complexity, new chemical technologies can provide systems-level views of cellular function. Here we discuss some of the molecular probes that illustrate this shift from a "one compound, one gene" pa...
متن کاملUlrike Eggert: Big things from small molecules
JCB • VOLUME 194 • NUMBER 3 • 2011 352 Y ou can learn a lot if you have the right tool to help your investigations along. But where those tools don’t exist, you may have to work on a different question. Ulrike Eggert isn’t about to let a little thing like the lack of a tool get in her way—she’ll just make her own. Since her postdoc in Tim Mitchison’s lab at Harvard (1), Eggert has used a combin...
متن کاملBig plans for small molecules: NIH launches chemical genomics initiative.
The National Institutes of Health, as part of its new " Roadmap for Medical Research, " is launching a major chemical genomics initiative. Directors of almost every institute within NIH gathered in late September to announce plans for the Roadmap, a special program to speed the transition of basic research to medical advances (see box p. 1741). Little attention was given to the chemical genomic...
متن کاملMicroRNAs in Cancer Management: Big Challenges for Small Molecules
In the last decade, the scientific community has been shaken by what we call the " noncoding revolution. " We have witnessed the discovery of an increasing amount of RNA molecules, which play a critical role in normal physiology as well as disease, without providing any protein product. The smallest regulatory RNA species, known as the ∼22 nucleotide-long microRNAs (miRNAs), were at the forefro...
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ژورنال
عنوان ژورنال: Journal of Molecular Cell Biology
سال: 2011
ISSN: 1674-2788
DOI: 10.1093/jmcb/mjr010